Journal of Organic Chemistry p. 1401 - 1409 (2016)
Update date:2022-08-02
Topics: Functionalization Cyclization Isolation and Purification Palladium catalyst C-H Activation Aromatic Oximes
Zhu, Zhongzhi
Tang, Xiaodong
Li, Xianwei
Wu, Wanqing
Deng, Guohua
Jiang, Huanfeng
An efficient strategy for synthesis of isoquinolines via Pd(II)-catalyzed cyclization reaction of oximes with vinyl azides or homocoupling of oximes is reported. Oximes could serve as a directing group and an internal oxidant in the transformation. This reaction features good functional group tolerance and provides a useful protocol for the synthesis of different kinds of isoquinolines under mild conditions. Some control experiments and 15N isotope labeling experiments were conducted for the mechanistic research. (Chemical Equation Presented).
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