Bioorganic and Medicinal Chemistry Letters p. 3113 - 3118 (1997)
Update date:2022-08-05
Topics:
Fei, Xiang-Shu
Tian, Wei-Sheng
Chen, Qing-Yun
A concise synthetic approach to 4-trifluoromethyl steroids, a novel class of steroid 5α-reductase inhibitors, is described. Direct trifluoromethylation of steroid olefinic bromide with methyl fluorosulfonyldifluoroacetate was used as a key step in the synthesis. The compound 4 exhibited highly inhibitory activity than Finasteride in in vitro assay.
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