Tetrahedron p. 4035 - 4050 (1997)
Update date:2022-08-03
Topics:
Claridge, Timothy D.W.
Long, James M.
Brown, John M.
Hibbs, David
Hursthouse, Michael B.
The synthesis of the title compound is described, involving 2-lithiation and phosphinylation of the coupled heterocycle in the final step. Attempts to resolve the phosphine by previously described methods led to its immediate racemisation, also observed more slowly in the PdCl2 complex, for which the X-ray structure is described. The phosphinamine formed a cationic pd(1,3-diphenylallyl) complex with high diastereoselectivity. By analysis of the solution stucture using NMR techniques, in comparison with the X-ray structure, some inferences about the mechanism of allylic alkylation with related heterotopic ligands can be drawn.
View MoreBeijing Green Guardee Technology CO,.LTD
Contact:+86-10-69706062
Address:F2 BLdj,5 No.37 Chaoqian Road
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd
website:http://www.jlpharms.com
Contact:+86-571-86982636
Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area
Shanghai Taibao Pharmaceutical Technology Co., Ltd
Contact:021-52217366
Address:shanghai
Jiaxing Anrui Material Technology Co., Ltd.
Contact:86-573-82651652 13305832579
Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
guide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Doi:10.1021/jf980440y
(1998)Doi:10.1016/j.saa.2013.12.017
(2014)Doi:10.1016/j.tetlet.2014.01.144
(2014)Doi:10.1016/S0277-5387(00)83459-2
(1994)Doi:10.1016/j.tet.2018.11.018
(2019)Doi:10.1021/jm00041a017
(1994)