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ChemComm
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DOI: 10.1039/C7CC06717H
COMMUNICATION
Journal Name
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were scaled up with regard to styrene) was performed under
the optimized conditions. After isolation of the product, the
yield was found to be 75% which proves the applicability of
large scale synthesis via this protocol (Scheme 6).
In summary, we have described an efficient and practical Ni-
catalyzed catalytic system for olefination of TAT via C-O bond
cleavage. This study is distinguished by using variety of
electrophilic TAT reagents prepared easily from cheap and
naturally abundant phenols in the presence of TCT targeting C-
O bond activation. Our methodology proves that TAT is an
efficient replacement for aryl halides in Heck cross-coupling
reactions. Remarkably, 3/1 molar ratio of phenol/TCT provides
a convenient and costly effective method to access number of
important olefins. Lastly, conversion of phenols to 1,2-
disubstituted olefins is a one-pot transformation in which
activation of the C-O bond in phenol with TCT reagent is
followed by the reaction of the in situ generated TAT with
styrenes.
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Notes and references
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‡ Footnotes relating to the main text should appear here. These
might include comments relevant to but not central to the
matter under discussion, limited experimental and spectral data,
and crystallographic data.
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4 | J. Name., 2012, 00, 1-3
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