Organic Letters p. 5910 - 5913 (2015)
Update date:2022-08-04
Topics:
Sugimoto, Kenji
Yajima, Hisanari
Hayashi, Yusuke
Minato, Daishiro
Terasaki, Sayuri
Tohda, Chihiro
Matsuya, Yuji
As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D3-membrane-associated, rapid response steroid-binding protein (1,25D3-MARRS) pathway. The biological assay revealed that the hybridization of characteristic δ-lactone in denosomin and the triene moiety in VD3 was effective to enhance the nerve re-extension activity in amyloid β (Aβ)-damaged neurons.
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Doi:10.1016/j.tetlet.2006.06.008
(2006)Doi:10.1021/jo9723570
(1998)Doi:10.1080/00397919808005068
(1998)Doi:10.1021/ja974205s
(1998)Doi:10.1016/S0040-4039(98)00194-4
(1998)Doi:10.1021/ja01146a015
(1951)