Tetrahedron p. 2809 - 2818 (1998)
Update date:2022-09-26
Topics:
Arnone, Alberto
Bernardi, Rosanna
Blasco, Francesca
Cardillo, Rosanna
Resnati, Giuseppe
Gerus, Igor I.
Kukhar, Valery P.
The stereoselective reduction of 3-trifluoromethylcyclohexanone (1a), (E)-1.1.1-(trifluoro-4-phenyl-3-buten-2-one (3a), and their unfluorinated analogues 1b and 3b has been performed with some growing microorganisms. Differences in the electronic and steric properties of the trifluoromethyl and methyl residues result in different chemo- and stereoselectivities in the microbial reduction of phenylbutenones 3a and 3b while cyclohexanones 1a and 1b showed strictly similar stereoselectivities. A new protocol based oil 13C NMR spectra of 2-phenylpropionic acid esters]has been used to assign the absolute configuration of the obtained secondary alcohols.
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