Tetrahedron p. 6567 - 6576 (1999)
Update date:2022-09-26
Topics:
Appendino, Giovanni
Belloro, Emanuela
Jakupovic, Sven
Danieli, Bruno
Jakupovic, Jasmin
Bombardelli, Ezio
Starting from taxanes available in multigram amounts from widespread ornamental yews (10-deacetylbaccatin III (4) and 2'-deacetoxyaustrospicatine (5)), two dimeric taxoids (3a, 3b) with potential dual target specificity (β-tubulin and P-gp) were synthesised. Both compounds lacked significant cytotoxicity, though 3b retained a strong activity in the tubulin depolimerisation assay.
View MoreYanCheng LongShen Chemical Co.,Ltd.
Contact:+86-515-86668866
Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
Suzhou Credit International Trading Co., Ltd
Contact:+86-512-65398039
Address:Qingdeng, Hightech. District, Suzhou
Hangzhou Haiqiang Chemical Co.,Ltd.
Contact:+86-571-86960370
Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
NINGBO YINLIANG FOREIGN TRADE CO., LTD.
Contact:+86-574-87834016 / 87898057
Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Doi:10.1021/ja00966a026
(1966)Doi:10.1021/jo00808a010
(1971)Doi:10.1016/S0040-4039(01)88738-4
(1969)Doi:10.1039/b000196l
(2000)Doi:10.1007/BF00771800
()Doi:10.1016/j.jfluchem.2004.09.002
(2004)