Organic Letters
Letter
DMSO, in the absence of thione or thiol, furnished 2-hydroxy-1-
phenylpropan-1-one (21) in 11% yield along with unreacted
propiophenone.
thank Dr. A. R. Ramesha (RL Fine Chem) for useful discussions.
Y.S. thanks CSIR, New Delhi, for an SPM fellowship.
REFERENCES
Based on these experiments and the literature preceden-
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ce,11d−h a tentative mechanism is proposed (Scheme 6).
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Scheme 6. Tentative Mechanism
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To the best of our knowledge, this is the first report of the
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ASSOCIATED CONTENT
* Supporting Information
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The Supporting Information is available free of charge on the
Experimental procedures, characterization data and
spectra for all compounds (PDF)
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AUTHOR INFORMATION
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Corresponding Author
ORCID
C. ACS Comb. Sci. 2015, 17, 147. (e) Billard, F.; Robiette, R.; Pospísi
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l, J.
J. Org. Chem. 2012, 77, 6358.
Notes
(14) Johansson Seechurn, C. C. C.; Kitching, M. O.; Colacot, T. J.;
Snieckus, V. Angew. Chem., Int. Ed. 2012, 51, 5062 and references cited
therein.
(15) The reaction with propiophenone derivatives led to a minor
amount of α-hydroxylation along with α-sulfenylation whereas no side
products were observed with acetophenone derivatives.
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
This work was supported by SERB (NO.SB/S1/OC-56/2013),
New Delhi, Indian Institute of Science and RL Fine Chem. We
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Org. Lett. XXXX, XXX, XXX−XXX