Organic Letters
Letter
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intramolecular cyclization, single-electron oxidation, C−N bond
cleavage/1,3-H transfer, and intramolecular nucleophilic addi-
tion sequence. Notable features of the protocol include mild
operating conditions, broad substrate scope, and good functional
group tolerance. The reaction could be readily scaled up to gram
scale, and the obtained difunctionalized indenones could be
transformed into diverse valuable compounds through suitable
late-stage derivatization and modification. This method may offer
an efficient tool for the synthesis of biologically or pharmaceuti-
cally useful molecules.
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(11) The structures of compounds 4c and 4e were determined by X-
CCDC 1523633 (4c) and 1537745 (4e) contain the supplementary
crystallographic data for this paper. These data can be obtained free of
charge from The Cambridge Crystallographic Data Centre via www.
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ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Typical experimental procedure and characterization data
Crystallographic data for compound 4c (CIF)
Crystallographic data for compound 4e (CIF)
AUTHOR INFORMATION
■
Corresponding Author
ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
Funding from the National Natural Science Foundation of China
(21472165, 21672186, 21602202) and the Program for the
Natural Science Foundation of Zhejiang Province
(LY16B020005) is acknowledged. We also thank the group of
Prof. Hongjun Ren at Zhejiang Sci-Tech University for their kind
help with the LC−HRMS measurements.
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