Journal of Organic Chemistry p. 6759 - 6764 (1992)
Update date:2022-09-26
Topics: Synthesis Oxidation Primary Amines Alkyl group Experimental Dimethyldioxirane
Crandall, Jack K.
Reix, Thierry
Several primary amines 2 have been oxidized with dimethyldioxirane (1) nder a variety of conditions.Mixtures of dimeric nitrosoalkanes 4 and oximes 5 were typically obtained with solutions of the oxidant in excess.In several instances, nitrones 12 were found as byproducts in these reactions.In situ oxidations using oxone in buffered aqueous solutions also gave nitrosoalkanes 4 and oximes 3 as important products; in addition, oxaziridines 11 were obtained in significant amounts in biphasic procedures containing methylene chloride.The corresponding nitroalkanes 5 were not formed in major amounts in either oxidation procedures, unless large excesses of oxidant were used.These results are discussed in terms of several competing processes which occur under the different reaction conditions.
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