Journal of Medicinal Chemistry p. 72 - 83 (1988)
Update date:2022-09-26
Topics: Compounds Experimental Ring-Substituted y1,2-Bis(4-hydroxyphenyl)ethylenediamine Dichloroplatinum(II) Complexes Hormone-Dependent Mammary Carcinoma Selective Effect
Karl, Johann
Gust, Ronald
Spruss, Thilo
Schneider, Martin R.
Schoenenberg, Helmut
et al.
<1,2-Bis(4-hydroxyphenyl)ethylenediamine>dichloroplatinum(II) complexes with one substituent in the 2-position (CH3, CF3, F, Br, I: meso- and dl-1-PtCl2, meso-(3-5)-PtCl2, meso-(7 and 8)-PtCl2) or two substituents in the 2,6-position (CH3, Cl: meso-2-PtCl2, meso- and dl-6-PtCl2) in both benzene rings were synthesized and tested for estrogenic and toxic activities.Two complexes (meso-6-PtCl2 and meso-7-PtCl2) possess both effects.In comparative tests on estrogen receptor positive and negative mammary tumors in cell culture (MCF 7, ER+ and MDA-MB 231, ER-) and in animals (MXT, ER+ and MXT, ER-, mouse), meso-6-PtCl2 shows a selective effect on the estrogen receptor positive mammary carcinoma.A further increase of efficacy was achieved with the water-soluble (sulfato)platinum(II) derivative (meso-6-PtSO4).On the DMBA-induced hormone dependent mammary carcinoma of the SD rat, meso-6-PtSO4 is significantly more active than its ligand (meso-6) and cisplatin.
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Doi:10.1134/S1070428007050028
(2007)Doi:10.1021/ja0464490
(2004)Doi:10.1021/ja00388a055
(1982)Doi:10.1055/s-2004-835646
(2004)Doi:10.1021/om050441x
(2005)Doi:10.1016/S0022-328X(00)89070-1
(1982)