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To summarize, we have described the synthesis and SAR
of novel azaheterocycle carbazole sulfonamides based
upon lead compound 7. 2,6-Dimethoxypyridinyl substi-
tuted carbazole sulfonamides 13 and 14 displayed potent
antiproliferative activities, slightly less active than lead
compound 7. Compound 13 showed good activities
against several human tumor cell lines. Interestingly,
preliminary data suggest that 14 does not phosphorylate
bcl-2 as did 7. Further studies are underway to explain
the differences in the activity of pyridinyl series. In vivo
efficacy studies for both 13 and 14 are ongoing.
Acknowledgments
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We thank the National Natural Science Foundation of the
PR China (30500630) and the Technology Development
Programof the Georgia State UniversityCenter of Biotech-
nology and Drug Design for support of this work.
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