Organic Letters
Letter
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(14) Crystallographic data for CCDC 1406153 (18) also lend
support to the structural elucidation of natural product 1:
C25H23N1O6, Mw = 433.44, monoclinic, a = 31.5153(16) Å, b =
8.7548(5) Å, c = 18.0436(10) Å, V = 4154.5(4) Å3, space group C2/c,
Z = 8, a total of 16928 reflections were collected in the range 1.55−
26.38°. Of these, 4254 were independent; for the observed data, wR2
= 0.0996, R1 = 0.0434.
(15) The minimum inhibitory concentration (MIC) of each
compound was determined using a broth microdilution method
following the guidelines of the Clinical and Laboratory Standards
Institute. Briefly, a 0.5 McFarland standard suspension of each test
isolate was prepared using colonies from an overnight sheep blood
agar plate and then diluted 1:100 in cation-adjusted Mueller−Hinton
broth (CAMHB) to obtain an final inoculum of 1−1.5 × 106 CFU/
mL. A 50 μL portion of the inoculum was then dispensed into wells
containing 50 μL of test compound prepared in CAMHB containing
0.2% DMSO. The plates were then incubated at 35 °C in ambient air
overnight and read at 20 and 24 h after incubation.
D
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