Synthetic Communications p. 2799 - 2813 (2008)
Update date:2022-08-31
Topics:
Diaz, Jose Luis
Fernandez-Forner, Dolors
Bach, Jordi
Lavilla, Rodolfo
A collection of new 1,3,5-trisubstituted piperidines has been synthesized starting from the commercially available 5-bromonicotinic acid. A unified, diastereoselective strategy allows the controlled access to both cis and trans stereochemistries. The heterocyclic compounds thus prepared bear multiple functional groups suitable for structural diversification and combichem protocols. Copyright Taylor & Francis Group, LLC.
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