Tetrahedron p. 9525 - 9540 (1997)
Update date:2022-08-10
Topics:
Kataoka, Yasutaka
Makihira, Isamu
Akiyama, Hiroaki
Tani, Kazuhide
Direct geminal diallylation of a carbonyl compound with allyl bromide has been achieved in the presence of a low-valent vanadium complex and zinc. The diallylation has been found to proceed stepwise and the two allyl groups were introduced successively. By applying this method, one-pot synthesis of asymmetric quaternary carbons has been accomplished. As the first alkylating reagent a combination of allyl bromide and zinc, a Grignard reagent, or an alkyllithium can be used. The second one should be the combination of a low- valent vanadium(II) complex and allyl bromide, benzyl bromide, or propargyl bromide. Strong oxophilicity of the low-valent vanadium facilitated the deoxygenative allylation.
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