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Table 2. Catalyst Effect on the Reaction
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Table 3. Catalyst Amount on the Reaction
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Conclusions
In summary, we have described a mild and efficient proto-
col for the synthesis of quinolines and polycyclic quinolines
via Friedländer condensation of 2-aminoaryl ketones with a-
methylene ketones using Cu(OTf)2 as catalyst. This method
not only provides an excellent complement to quinolines syn-
thesis via Friedländer annulation, but also avoids the use of
hazardous acids or bases and harsh reaction conditions.
Acknowledgements We gratefully acknowledge financial support from
the Research Council of Razi University.