Organic Process Research and Development p. 2116 - 2123 (2016)
Update date:2022-08-23
Topics:
Yu, Zhiqun
Dong, Hei
Xie, Xiaoxuan
Liu, Jiming
Su, Weike
An expeditious process for the highly efficient synthesis of methyl 2-(chlorosulfonyl)benzoate was described, which involved the continuous-flow diazotization of methyl 2-aminobenzoate in a three-inlet flow reactor via a cross joint followed by chlorosulfonylation in the tandem tank reactor. The side reaction such as hydrolysis was decreased eminently from this continuous-flow process even at a high concentration of hydrochloric acid. The mass flow rate of methyl 2-aminobenzoate was 4.58 kg/h, corresponding to an 18.45 kg/h throughput of diazonium salt solution. The potential of inhibiting parallel side reactions by conducting in a flow reactor was successfully demonstrated in this method.
View MoreLishui Nanming Chemical Co., Ltd
Contact:+86-0578-2134101,2697830
Address:No.19 Tongji Road Shuige Industrial zone
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
website:http://www.shydtec.com
Contact:86-21-57721279
Address:Science and Technology Park, Songjiang District, Shanghai, China
Shanghai Balmxy Pharmaceutical Co., Ltd
Contact:0086-21-24206007
Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Shanghai Massive Chemical Technology Co., Ltd.
website:http://www.massivechem.com/
Contact:+86 21 34943721
Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Doi:10.1177/021849230000800111
()Doi:10.1134/S1070363212070158
(2012)Doi:10.1246/bcsj.50.2269
(1977)Doi:10.1021/op980075b
(1999)Doi:10.1021/jo00051a060
(1992)Doi:10.1021/ja017376c
(2002)