Article
Sarkar et al.
a
Table 3. Recycling of the MCM-41-supported chiral ligand 3
Malaysia. Fund no. RDU140124.
b
c
Ketone
Cycle
Conv. (%)
E.e. (%)
d
d
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1
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81 (25)
86 (94)
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conditions (Table 2 5a). The supported catalyst was recov-
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and directly used to the next reaction without further addi-
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CONCLUSIONS
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We have synthesized MCM-41-supported chiral N-
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rived from relatively cheap optically pure (1R,2R)-diami-
nocyclohexane, for the asymmetric transfer hydrogenation
of ketones. The catalyst displayed good catalytic activity
and enantioselectivity in the asymmetric transfer hydroge-
nation of aromatic ketones in aqueous medium, and the
substrates with electron-donating groups had less enantio-
selectivity than those with electron withdrawing groups.
Further synthesis on mesoporous silica-supported chiral
ligands and their use to asymmetric catalysis are underway.
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ACKNOWLEDGEMENT
30. Song, C. E.; Lee, S.-g. Chem. Rev. 2002, 102, 3495.
This work is supported by the Ministry of Education
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4
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