Journal of the American Chemical Society
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DiBenedetto, T. A.; Kim, S.; Ackerman, L. K. G.; Weix, D. J. J. Am.
formation and does not require the use of expensive tran-
sition metals or ligands. This work constitutes a new, mild
strategy for the decarboxylative functionalization of aro-
matic carboxylic acids, which should see broad applica-
tion extending beyond borylation.
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ASSOCIATED CONTENT
Experimental procedures, mechanistic experiments, and
spectral data. This material is available free of charge via
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AUTHOR INFORMATION
(11) (a) Wang, G.; Zhang, H.; Zhao, J.; Li, W.; Cao, J.; Zhu, C.; Li,
S. Angew. Chem. Int. Ed. 2016, 55, 5985. (b) Wang, G.; Cao, J.;
Gao, L.; Chen. W.; Huang, W.; Cheng, X.; Li, S. J. Am. Chem. Soc.
2017, 139, 3904.
Corresponding Author
(12) (a) Boronic Acids: Preparation and Applications in Organic
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(14) For recent transition metal-free borylation reactions with
miscellaneous reagents see; (a) Légaré, M.-A.; Courtemanche,
M.-A.; Rochette, É.; Fontaine, F.-G. Science 2015, 349, 513. (b) De
Vries, T. S.; Prokofjevs, A.; Vedejs, E. Chem. Rev. 2012, 112, 4246.
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Organomet. Chem. 2015, 49, 39. (e) Warner, A. J.; Lawson, J. R.;
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(f) Zhang, J.; Wu, H.-H., Zhang, J. Eur. J. Org. Chem. 2013, 6263.
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W.; Hellal, A.; Albini, M.; Rouden, J.; Blanchet, J. Chem. Eur. J.
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(15) While this manuscript was under revision the borylation of
alkyl N-hydroxyphthalimide esters was disclosed; Li, C.; Wang,
J.; Barton, L. M.; Yum S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu,
A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.
Science 2017, DOI: 10.1126/science.aam7355.
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(b) Guo, L.; Rueping, M. Chem. Eur. J. 2016, 22, 16787. (c) Hu, J.;
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(17) See supporting information for further information.
(18) Horn, E. J.; Rosen, B. R.; Chen, Y.; Tang, J.; Chen, K.; East-
gate, M. D.; Baran, P. S. Nature 2016, 533, 77.
(19) (a) Collins, K. D.; Glorius, F. Nat. Chem. 2013, 5, 597. (b)
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Notes
The authors declare no competing financial interests.
ACKNOWLEDGMENT
We thank Felix Schäfers, Dr. Adrián Gómez-Suárez, Adri-
an Tlahuext-Aca and Mario P. Wiesenfeldt for experi-
mental assistance and helpful discussions. Generous fi-
nancial support from the Alexander von Humboldt Foun-
dation (L.C.) and the Deutsche Forschungsgemeinschaft
(Leibniz Award) are gratefully acknowledged.
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