Chinese Chemical Letters p. 765 - 767 (2011)
Update date:2022-08-16
Topics:
Li, Xu Qin
Yang, Yun Xu
Wang, Wei Li
Hu, Bin
Xue, Hui Min
Zhang, Tian Yi
Zhang, Xue Tao
A practical chemical synthesis of l-carnitine (1) has been accomplished from (R)-3-chloro-1,2-propanediol ((R)-4), which is a main by-product originated from (R,R)-Salen Co(III) catalyzed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin. (R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite ((R)-5). The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
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