March 2007
597
C-4ꢆ position (catechol subunit on ring B) is the most impor-
tant factor for inhibition of tyrosinase activity.
We discovered that (2R,3R)-(ꢃ)-taxifolin (1) isolated from
Benitade may possibly be a of new tyrosinase inhibitor alter-
native to cosmetic agents such as arbutin and kojic.
Acknowledgements This work was supported by “High-
Tech Research Center” project for Private Universities:
matching fund subsidy from MEXT (Ministry of Education,
Culture, Sports, Science and Technology of Japan), 2004—
Fig. 3. Chemical Structures of Compounds 1—3
2008 and we thank Director Tatsumi Watanabe of Hiroshima
Tade Cooperation for supplying Benitade in this study.
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