Journal of Medicinal Chemistry p. 369 - 373 (1982)
Update date:2022-08-17
Topics:
Bennett, Stephen
Sharples, Derek
Brown, Jeffrey R.
Anthraquinones substituted at the 2 position with a basic side chain were prepared, and their binding to DNA was evaluated.All compounds showed an intercalative mode of binding to DNA; 1,4-dihydroxy derivatives bound more strongly than 1-hydroxy or nonhydroxylated compounds.Greatest DNA-binding activity was found where there were five atoms between the anthraquinone ring and the basic nitrogen.
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