Dyes and Pigments p. 852 - 858 (2017)
Update date:2022-08-30
Topics:
Kang, Jin
Huo, Fangjun
Yue, Yongkang
Wen, Ying
Chao, Jianbin
Zhang, Yongbin
Yin, Caixia
Hypochlorous acid (HOCl)/hypochlorite (OCl?) plays an important role in immune system, while as a major reactive oxygen species (ROS) in living systems, HOCl/OCl? is responsible for some human diseases. Thus it is critical to monitor the change of HOCl in the living cells. In this study, we prepared a novel fluorescent probe BDP-OX based on BODIPY-Dialdoxime for HOCl/OCl? determination, which displayed a remarkable “ratio” fluorescence response towards HOCl/OCl? with a fast response (completed within 15?s). The ratios of emission intensities at 538–589?nm (I538/I589) displayed a large increase from 0.015 to 2.88 with this probe. More importantly, confocal fluorescence imaging with BDP-OX showed separated signals in the presence of HOCl/OCl? in living A549?cells, that indicating BDP-OX have potential biological application prospects.
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