Applied Catalysis A: General p. 10 - 15 (2016)
Update date:2022-08-10
Topics:
Fu, Jie
Mo, Jing
Zhang, Jing
Lu, Xiuyang
2,3,4,5-Tetrafluorobenzoic acid is an important pharmaceutical intermediate. A green technology for the decarboxylation of tetrafluorophthalic acid to 2,3,4,5-tetrafluorobenzoic acid in NH3-enriched high temperature liquid water (HTLW) was developed. Tetrafluorophthalic acid could undergo the decarboxylation with the catalysis of NH3 to 2,3,4,5-tetrafluorobenzoic acid in HTLW. A conversion of 98.1% and selectivity of 96.5% were achieved at 453.15 K for 1.5 h with an ammonia concentration of 13.4 mmol/L. The effects of ammonia concentration, initial concentration of reactant and reaction temperature were then investigated and correlated using a derivated equation. The results indicated that adequate addition of ammonia could adjust the pH of the reaction medium into 2.2-2.4, where the dominant form of the decarboxylation is the monovalent anion. Moreover, the kinetic data at different temperatures were fitted by a first-order equation, and the rate constants at each temperature and an activation energy of 190 kJ/mol were obtained.
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Doi:10.1021/acs.orglett.5b00452
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(1934)Doi:10.1016/S0040-4020(01)00921-8
(2001)Doi:10.1016/S0957-4166(00)00119-1
(2000)Doi:10.1023/A:1005591826613
(2000)Doi:10.1016/j.jallcom.2018.01.058
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