Communication
ChemComm
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Fig. 3 Fluorescence images of probe NCR sequentially sensing Cys/Hcy,
GSH and H
2
S in living HeLa cells. Cells were incubated with (A) NEM
0.5 mM, 30 min), subsequently incubated with probe NCR (5 mM, 30 min);
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(
(
(
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B and C) NEM (0.5 mM, 30 min), subsequently incubated with Cys/Hcy
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with 500 mM NaHS for 30 min; and (D) NEM (0.5 mM, 30 min), subse-
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(
0 min), and continued to be treated with 500 mM NaHS for 30 min
blue channel of 440–490 nm and red channel of 575–620 nm). Scale bar:
0 mm.
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The 121 nm separation in emission maxima between the blue
and red channels allows for minimal or no signal overlap and
high selectivity. Furthermore, fluorescence imaging studies in
live cells demonstrated that probe NCR is able to simulta-
(
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neously monitor endogenous and exogenous H
2
S, Cys/Hcy, 16 J. Zhang, X. Ji, J. Zhou, Z. Chen, X. Dong and W. Zhao, Sens.
Actuators, B, 2018, 257, 1076–1082.
and GSH via dual-color imaging. This study may provide an
effective tool for further exploration of the functions of various
biothiol species in biological systems.
This work was supported by the National Key Research and
Development Program of China (Grant No. 2018YFA0507204), the
National Natural Science Foundation of China (Grant No. 21672115)
and the State Key Laboratory of Medicinal Chemical Biology.
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Conflicts of interest
(
There are no conflicts to declare.
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J. L. Sessler, C. Kang and J. S. Kim, J. Am. Chem. Soc., 2012, 134,
12668–12674; (e) M. H. Lee, J. L. Sessler and J. S. Kim, Acc. Chem.
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