Synthetic Communications p. 3611 - 3620 (2009)
Update date:2022-08-25
Topics:
McCrea-Hendrick, Maddy
Nichols, Christopher J.
The synthesis of the tetraenylpiperidine 12, which has the same core structure as the natural product corydendramine A, has been completed in eight steps starting from 2-piperidinemethanol 3 and trans,trans-2,6-nonadienal 6. The key step of the synthesis was a Julia coupling of sulfone (10) with aldehyde (5) to form a conjugated triene.
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