Synthetic Communications p. 3880 - 3887 (2009)
Update date:2022-08-16
Topics:
Ghosh, Samir
Kumar, A. Sanjeev
Soundararajan
Mehta
A highly efficient approach to the synthesis of the angiotensin II receptor antagonist valsartan (Diovan), one of the most important agents used in antihypertensive therapy today is described. The formation of the aryl-aryl bond represents the key step of its synthesis, which has been done by simple nucleophelic aromatic substitution on aryloxazoline with good yield and purity. Copyright Taylor & Francis Group, LLC.
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