Journal of the American Chemical Society
Communication
(8) For recent reviews on alcohol-mediated carbonyl reductive
coupling, see: (a) Nguyen, K. D.; Park, B. Y.; Luong, T.; Sato, H.;
Garza, V. J.; Krische, M. J. Metal Catalyzed Reductive Coupling of
Olefin-Derived Nucleophiles: Reinventing Carbonyl Addition. Science
2016, 354, aah5133. (b) Kim, S. W.; Zhang, W.; Krische, M. J.
Catalytic Enantioselective Carbonyl Allylation and Propargylation via
Alcohol Mediated Hydrogen Transfer: Merging the Chemistry of
Grignard and Sabatier. Acc. Chem. Res. 2017, 50, 2371.
(9) For recent reviews on the application of alcohol-mediated
carbonyl reductive coupling in target-oriented synthesis, see:
(a) Dechert-Schmitt, A.-M. R.; Schmitt, D. C.; Gao, X.; Itoh, T.;
Krische, M. J. Polyketide Construction via Hydrohydroxyalkylation
and Related Alcohol CH Functionalizations: Reinventing the
Chemistry of Carbonyl Addition. Nat. Prod. Rep. 2014, 31, 504.
(b) Feng, J.; Kasun, Z. A.; Krische, M. J. Enantioselective Alcohol C-
H Functionalization for Polyketide Construction: Unlocking Redox-
Economy and Site-Selectivity for Ideal Chemical Synthesis. J. Am.
Chem. Soc. 2016, 138, 5467. (c) Schwartz, L. A.; Krische, M. J.
Hydrogen-Mediated C-C Bond Formation: Stereo- and Site-Selective
Chemical Synthesis Beyond Stoichiometric Organometallic Reagents.
Isr. J. Chem. 2018, 58, 45.
ACKNOWLEDGMENTS
■
The Robert A. Welch Foundation (F-0038), and the NIH-
NIGMS (R01 GM093905, 1 S10 OD021508-01) are acknowl-
̀
̧ o de Amparo a Pesquisa
̃
edged for financial support. Fundaca
do Estado de Sao Paulo (FAPESP) is acknowledged for a
̃
research internship scholarship support (F.D.F. 2017/18487-
4) and for research grants (2013/07607-8, 2014/25474-8,
2016/12541-4). CONICET is acknowledged for financial
support (PIP 11220130100660CO). The authors thank Dr. S.
S. Thomasi for NMR data for natural phosdiecin A. R.A.P. is
grateful to the academic guidance received from Albert J.
Kascheres. R.A.P., A.M.S. and F.D.F. dedicate to Professor
́
Edmundo A. Ruveda (in memoriam).
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