Synthesis p. 819 - 820 (1996)
Update date:2022-08-29
Topics:
Braun, Manfred
Galle, Dietmar
The cholesterol absorption inhibitor (3R,4S)-1 is synthesized in 91% ee by a stereoselective condensation of doubly deprotonated ester 2 and imine 3. The optical purity of the trans-diastereomer 1 obtained as the major isomer (trans/cis, 94:6) is enhanced to >98% ee by a single recrystallization.
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