A Microfluidic Approach to the Rapid Screening
FULL PAPERS
complex was prepared in situ by the 1:1 stoichiometric reac-
tion of 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride
and palladium acetate. The palladium dimer complex [Pd2
Acknowledgements
PWM is grateful to the EPSRC for the award of a Life Scien-
ces Interface fellowship (EP/E039278/1) and to GSK for
funding. Katherine Gerry and James Hall are acknowledged
for their assistance with GC analysis.
A
ACHTUNGTRENNUNG{m-PACHTUNGTRENNUNG(t-Bu)2ACHTUNGTRENNUNG(Bph-H)] (Bph-H=biphenyl) was pre-
AHCTUNGTRENNUNG
Bu)3]2} complex was prepared by a modified procedure to
that previously reported in the literature.[56] To a suspension
of [Pd2ACHTUNGTRENNUNG(dba)3] (1.0 mmol, 0.916 g) in toluene (80 mL) was
added tri-tert-butylphosphine (4.95 mmol, 1.0 g) and the re-
action mixture stirred for 48 h at ambient temperature. The
solution was then filtered into a new flask via cannula and
toluene removed under reduced pressure. This crude solid
was then dissolved in dry diethyl ether (30 mL) and placed
in a freezer at À358C overnight to yield white crystals. The
supernatant was removed using a cannula and the crystals
washed with dry diethyl ether (2ꢃ4 mL) and dried under re-
duced pressure; yield. 0.56 g (55%) 1H NMR (benzene-d6,
400 MHz): d=1.65–1.62 (m, 54H), (3JP, H =5.7 Hz);
31P{1H} NMR (benzene-d6, 162 MHz): d=84.9 (s).
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