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ChemComm
DOI: 10.1039/C6CC08977A
COMMUNICATION
Chemical Communications
naturally high GSH-expressing cancer cells by inducing
mitochondrial dysfunction, DNA damage and subsequent
apoptosis.
This work was supported by The Ministry of Science, ICT &
Future Planning (MSIP) of National Research Foundation of
Korea
(No.
2009-0081566
for
JSK
and
NRF-
2
0158A2A1A01005389 for SGC). This research was supported
by the Korea Research Fellowship Program funded by the
Ministry of Science, ICT and Future Planning through the
National Research Foundation of Korea (2016H1D3A1938052
for PV).
Notes and references
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As both mitochondrial alkylative DNA damage as well as
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mitochondrial membrane disruption by AIE dyes are known
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highly GSH-dependent manner. Considering the observed
differential GSH expression levels in cancerous cells, this effort
to develop new drugs activated by intracellular GSH should
give significant selectivity, with clear advantages for cancer
chemotherapy. Our present study demonstrates that prodrug
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700
bearing theranostic
1 induces a cytotoxic effect selectively on
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