The Synthesis and Immunotropic Activity of a New Azathioprine Analog
581
AFC, % of control
spleen to less than 10% of control). The TI of compound
C-87 was significantly greater than that of Az (13.3 and 8.0
respectively).
2
1
0
At the final stages of the study, the actions of equitoxic
doses of Az and compound C-87 on thymus-dependent
(
RBC, Fig. 2) and thymus-independent (Vi-Ag, Fig. 3) im-
mune responses were studied in parallel. As in the preceding
part of the study, compound C-87 gave more effective sup-
pression of the immune responses to both antigens than Az.
Neither C-87 nor Az showed any preferential suppression of
T-dependent or T-independent immune responses.
Thus, compound C-87 is of interest in terms of further
studies as a potential immunodepressant.
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Fig. 3. The effects of compound C-87 and azathioprine on immune
responses to Vi antigen. Substances were given at equitoxic doses
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