Bioorganic and Medicinal Chemistry p. 2741 - 2752 (2019)
Update date:2022-08-11
Topics:
Semreen, Mohammad H.
El-Gamal, Mohammed I.
Ullah, Saif
Jalil, Saquib
Zaib, Sumera
Anbar, Hanan S.
Lecka, Joanna
Sévigny, Jean
Iqbal, Jamshed
A new series of sulfonate derivatives 1a–zk were synthesized and evaluated as inhibitors of nucleotide pyrophosphatases. Most of the compounds exhibited good to moderate inhibition towards NPP1, NPP2, and NPP3 isozymes. Compound 1m was a potent and selective inhibitor of NPP1 with an IC50 value of 0.387 ± 0.007 μM. However, the most potent inhibitor of NPP3 was found as 1x with an IC50 value of 0.214 ± 0.012 μM. In addition, compound 1e was the most active inhibitor of NPP2 with an IC50 value of 0.659 ± 0.007 μM. Docking studies of the most potent compounds were carried out, and the computational results supported the in vitro results.
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Doi:10.1055/s-1991-26489
(1991)Doi:10.1021/ja047281l
(2004)Doi:10.1016/j.tet.2014.03.029
(2014)Doi:10.1016/j.cell.2006.02.047
(2006)Doi:10.1016/j.apcata.2017.02.004
(2017)Doi:10.1002/hc.20454
(2008)