Inorganica Chimica Acta (2019)
Update date:2022-08-17
Topics:
Grimley, Eugene
Irradiation of solutions of the complex ion, [PtCl6]2?, in the presence of NH4+ results in photochemical changes in which the chlorides of the complex are replaced by 1, 2, or more ammonia molecules with the charge decreasing by one for each replacement. These replacements were followed by changes in absorption spectra and electrochromatographic patterns and were isolated by continuous curtain electrochromatography. Each species had unique effects on the bacteriological growth of Escherichia coli. The doubly negative species is a bacteriocide and the singly negative species had little effect on either cell growth or cell division. The neutral species caused significant inhibition of cell division, formed filamentous cells, and was bacteriologically determined to be [PtCl4(NH3)2]. The cis and trans isomers of [PtCl4(NH3)2] were synthesized and tested. Bacteriological studies comparing both isomers of the neutral species showed that the trans isomer had little effect on inhibition of cell growth or cell division, whereas the cis isomer was fully efficient. The starting complex for synthesis of the cis complex, cis-[PtCl2(NH3)2], known medically as cisplatin, was biologically tested and also found to be fully effective in inhibiting cell growth.
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