2
68
J Biol Inorg Chem (2010) 15:259–269
the monolayer is dQ/dt (lmol/s). The initial drug concen-
National Cancer Institute (1R01CA120009, 1R21CA139386-01;
Q.P.D.).
tration on the apical side is C (lM). The surface area of
0
2
the monolayer is A (cm ). The efflux ratio was defined as
the ratio of the basolateral side to the apical side apparent
permeability coefficient and the apical side to the baso-
lateral side apparent permeability coefficient.
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Acknowledgments This work was supported by Shandong Univer-
sity, the American Lebanese Syrian Associated Charities (ALSAC),
and St. Jude Children’s Research Hospital (B.Y.)., and research funds
from the Karmanos Cancer Institute of Wayne State University
(Q.P.D.), the Department of Defense Breast Cancer Research Pro-
gram (W81XWH-04-1-0688, DAMD17-03-1-0175; Q.P.D.) and the
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