10.1002/anie.201706401
Angewandte Chemie International Edition
COMMUNICATION
to obtain β-fluorinated carboxylic acid derivatives. Further
exploration of the mechanism and new transformation is in
progress in our laboratory.
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Acknowledgements
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We are grateful for financial support from the National Basic
Research Program of China (973-2015CB856600), the National
Nature Science Foundation of China (Nos. 21532009, 21472219
and 21672236), Program of Shanghai Academic/ Technology
Research Leader (17XD1404500), the Strategic Priority Research
Program (No. XDB20000000) and Key Research Program of
Frontier Science (No. QYZDJ-SSW-SLH055) of the Chinese
Academy of Sciences. This research was partially supported by
CAS Interdisciplinary Innovation Team.
Keywords: alkenes • fluorination • carbonylation • hypervalent
iodine • palladium
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the catalytic cycle, the new signal at -131.8 ppm (19F NMR) was indeed
observed, which is possibly consisted with the compound ArIFOAc.
For details, see the Supporting Information (SI).
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[15] If reaction undergoes path b process in Scheme 2, product syn-4d-d1
with opposite stereochemistry should be obtained. For more discussion,
see SI.
[16] In the absence of additive Me4NOAc, the reaction provide the same
stereochemistry. For details, see SI.
[ 17 ] During the reviewing process, referee recommends that, in the
presence of Me4NOAc, a six-membered oxetenium ion generated from
int.IV (Nu = OAc) possibly acts as a key intermediate for the final
nucleophilic fluorination, which can not be excluded at the moment.
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