Journal of Medicinal Chemistry p. 1361 - 1363 (1984)
Update date:2022-08-11
Topics:
Fang
Takemori
Portoghese
Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.
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