Journal of Organic Chemistry p. 10953 - 10961 (2019)
Update date:2022-08-16
Topics:
Jo, Jeyun
Jeong, Myeonggyo
Ahn, Ji-Su
Akter, Jinia
Kim, Hyung-Sik
Suh, Young-Ger
Yun, Hwayoung
The first total synthesis of anmindenol A is described in four steps. A notable feature of the synthetic route includes the efficient construction of the 3,10-dialkylsubstituted benzofulvene core via a stereoselective vinylogous Stork enamine aldol condensation. The strategy provided a blueprint for the practical preparation of derivatives with modifications in the C-10 alkyl substituents. The novel derivatives inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells.
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