Journal of Physical Chemistry p. 3405 - 3410 (1982)
Update date:2022-08-16
Topics:
Brault, D.
Neta, P.
The reduction of ferrideuteroporphyrin by α-hydroxyisopropyl radicals is investigated in acidic 2-propanol and acidic 2-propanol-water mixtures by means of steady-state and pulse radiolysis.The rate constant of the reaction is much higher (k ca. 1.3E9 M-1s-1) than that reported for neutral solutions emphasizing the effect of the positive charge carried by the ferric porphyrin in acidic solutions (due to protonation of the alkoxide ligand).Competition kinetic experiments using p-nitroacetophenone as a reference solute show that α-hydroxyisopropyl radicals are readily scavenged by halothane (CF3CHClBr), leading to <*> radicals.Pulse irradiation of ferriporphyrin solutions containing halothane allows investigation of the reaction of <*> radicals with either ferric or ferrous porphyrins depending on the halothane concentration.No reaction of <*> radicals with ferriporphyrin can be detected (k = 1E6 M-1s-1).On the other hand, a nearly diffusion-controlled reaction is observed between <*> radicals and ferrous porphyrin leading to the ?-bonded alkyl complex of the ferric porphyrin (PFeIIICF3CHCl, where CF3CHCl stands for the alkyl anion).These results are discussed with regard to the reactivity of other alkyl radicals.The relevance to biological models of toxicity of halothane (a widely used anesthetic agent) is outlined.
View MoreYantai Derun Liquid Crystal Materials Co. Ltd.
website:http://www.ytderun.com
Contact:86-535-6300169
Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
Suzhou Wedo Chemicals Co., Ltd.
Contact:86 512 58100425
Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Shanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Hangzhou Yingshanhua Pigment Chemicals Co.,Ltd.
Contact:+86-0150-58101658
Address:Nanyang Economic DevelopmentZong,Xiaoshan,Hangzhou,China
Jintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Doi:10.1021/ja5062467
(2014)Doi:10.1021/jf050420d
(2005)Doi:10.1021/acs.orglett.0c03766
(2021)Doi:10.1021/om00140a033
(1986)Doi:10.1021/acs.joc.0c01789
(2020)Doi:10.1039/c9nj02564b
(2019)