Journal of Organic Chemistry p. 2747 - 2750 (1993)
Update date:2022-08-11
Topics:
Echalier, Frederique
Constant, Olivier
Bolte, Jean
This paper reports the activity of glutamic oxalacetic aminotransferase (GOT) from pig heart and bacteria for racemic 4-hydroxy-, 4-methyl-, and 4-ethyl-2-ketoglutaric acids.These compounds are good substrates for GOT with Vmax values of, respectively, 70, 90, and 130 percent relative to the natural substrate, 2-ketoglutaric acid.GOT displays high enantioselectivity toward 4-methyl-2-ketoglutaric acid and 4-ethyl-2-ketoglutaric acid; the synthesis of both diastereoisomers of the corresponding 4-substituted L-glutamic acids is thus possible.
View MoreGuilin Zhenda Bio-Tech Co., Ltd.
Contact:86-773-3568977
Address:-Yangtang shangshui industry park, Lingui county,
website:http://www.sjzthld.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Contact:0086 533 2282832
Address:Zibo,Shandong
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building, 132 Renmin Road
Doi:10.1039/c8ra08624a
(2018)Doi:10.1016/j.mencom.2013.09.006
(2013)Doi:10.1021/jo061502j
(2006)Doi:10.1002/zaac.200390102
(2003)Doi:10.1021/j100341a070
(1989)Doi:10.1016/S0040-4039(01)85785-3
(1978)