Organic and Biomolecular Chemistry p. 5349 - 5366 (2019)
Update date:2022-08-11
Topics:
Singh, Iqubal
Luxami, Vijay
Paul, Kamaldeep
A series of novel naphthalimide-benzimidazoles was designed and synthesized for the first time and studied for their effect on antiproliferative activity. Some of these compounds possessed good antitumor activity towards the tested cancer cell lines. Noticeably, (diethylamino)ethyl 15 and (dimethylamino)ethyl 23 derivatives displayed superior antiproliferative activity towards human cancer cell lines with MG-MID GI50 values of 1.43 and 1.83 μM, respectively. Preliminary investigation revealed that compounds 15 and 23 might bind with ct-DNA through the intercalation mode which is responsible for potent bioactivity. Moreover, transportation behaviour indicated that these molecules could efficiently bind to and be carried by bovine albumin, and the hydrogen bonding and hydrophobic interactions played important roles in interaction with serum albumin.
View Moreguide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Laohekou huacheng Trade Co., Ltd.
Contact:+86-710-8360685
Address:No. 85, Beijing Road, Laohekou City, Hubei Province, China
Contact:0512-62706911
Address:No.289 Yinzhong South Road Wuzhong Economic Development District,Suzhou,China
Huangshi Shennong Chemical Technology Co., Ltd
Contact:+86-714-3072290
Address:Eastern industrial park , Tieshan district , Huangshi city ,Hubei province , China
WENZHOU M&C FOREIGN TRADE CO.,LTD.
Contact:+86-577-88862917
Address:No.8 Liming West Road,Wenzhou,zhejiang,China
Doi:10.1016/j.bmcl.2012.12.038
(2013)Doi:10.1021/jo00371a032
(1986)Doi:10.1016/j.crci.2016.03.011
(2016)Doi:10.1002/jps.2600580606
(1969)Doi:10.1039/c8cy01691g
(2018)Doi:10.1016/j.saa.2013.09.134
(2014)