Journal of Organic Chemistry p. 9446 - 9453 (2015)
Update date:2022-08-11
Topics:
Yu, Mingwu
Wang, Zhiqian
Hu, Junbin
Li, Shunlai
Du, Hongguang
A novel copper-catalyzed intramolecular dehydrogenative alkoxylation of purine nucleosides has been developed successfully, providing the 5′-O,8-cyclopurine nucleosides in one-step with a yield up to 90%. The method, which utilized an inexpensive CuCl catalyst and a di-tert-butyl peroxide (DTBP) oxidant was suitable in a broad substrate scope and proceeded well even in gram scale.
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