Tetrahedron p. 14599 - 14614 (1997)
Update date:2022-08-17
Topics:
Jones, Graham B.
Mathews, Jude E.
The preparation and intercalative ability of the pyrrolo[9,10-b]phenanthrene nucleus is described. Functionalization of the nucleus was achieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system.
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