Journal of Medicinal Chemistry p. 960 - 962 (1980)
Update date:2022-08-11
Topics:
Vincek
Martin
Aceto
Bowman
4,4-Ditritio-(-)nicotine (5) of high specific activity (4.7 Ci/mmol) has been synthesized from (-) nicotine via the readily prepared 4,4-dibromocotinine. Scatchard analysis of the binding of 5 to the crude mitochondrial fraction of whole rat brain revealed a K(a) of 4.7 x 106 M-1 and 13 fmol of binding sites/mg of protein.
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