Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists

DOI: 10.1016/S0960-894X(99)00082-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 647 - 652 (1999)

Update date:2022-08-29

Topics:

Authors:

Zarrinmayeh, Hamideh

Zimmerman, Dennis M.

Cantrell, Buddy E.

Schober, Douglas A.

Bruns, Robert F.

Gackenheimer, Susan L.

Ornstein, Paul L.

Hipskind, Philip A.

Britton, Thomas C.

Gehlert, Donald R.

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Article abstract of DOI:10.1016/S0960-894X(99)00082-7

A series of benzimidazoles (4) was synthesized and evaluated in vitro as potent and selective NPY Y1 receptor antagonists. Substitution of the piperidine nitrogen of 4 with appropriate R groups resulted in compounds with more than 80-fold higher affinity

Full text of DOI:10.1016/S0960-894X(99)00082-7

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Article Doi

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists

DOI: 10.1016/S0960-894X(99)00082-7

Source and publish data:

Authors:

Article abstract of DOI:10.1016/S0960-894X(99)00082-7

Full text of DOI:10.1016/S0960-894X(99)00082-7

Products guided by the article

R&D Labs maybe for 52914-23-5

Relevant to this article

Modulation of Self-Assembly Enhances the Catalytic Activity of Iron Porphyrin for CO2 Reduction

Vibrational spectra of β-lactams. I. 2-Azetidinone and its isotopic compounds

Solid-phase synthesis on functionalised fluoropolymer resins. Part 2: Preparation and properties of functional merrifieldtype resins possessing a perfluorinated polymer backbone

A SPIROSTANOL GLYCOSIDE FROM AGAVE CANTALA

Energy distribution of the fragments produced by photodissociation of CS2 at 193 nm

Oxidative Fragmentation of Aspalathin Leads to the Formation of Dihydrocaffeic Acid and the Related Lysine Amide Adduct

Modulation of Self-Assembly Enhances the Catalytic Activity of Iron Porphyrin for CO₂ Reduction