Bioscience, Biotechnology and Biochemistry p. 1415 - 1417 (1997)
Update date:2022-08-16
Topics:
Nakagawa
Irie
Nakamura
Ohigashi
Hayashi
The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.
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