Basic information
- Name:
Guanidine hydrochloride
- CAS No.:
50-01-1
- Molecular Structure:
- Formula:
- CH5N3.HCl
- Molecular Weight:
- 95.53
- Deleted CAS:
- 94369-44-5|915070-50-7|87667-20-7|420-13-3|15827-40-4|139693-44-0
- Synonyms:
- Guanidine,monohydrochloride (8CI,9CI);Buffer AL;Guanidine chloride;Guanidinehydrochloride;Guanidinium chloride;Guanidinium hydrochloride;
- EINECS:
- 200-002-3
- Density:
- 1.18 g/mL at 25 °C(lit.)
- Melting Point:
- 180-185 °C(lit.)
- Boiling Point:
- 132.9 °C at 760 mmHg
- Flash Point:
- 34.2 °C
- Solubility:
- 2280 g/L (20 °C) in water
- Appearance:
- White cryst. powder
- Hazard Symbols:
Xn, 
Xi- Risk Codes:
- 22-36/38
- Safety Description:
- 26-36-22 Details
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Chemistry
Product Name: Guanidine hydrochloride (50-01-1)
Molecular Formula: CH6ClN3
Molecular Weight: 95.53g/mol
Mol File: 50-01-1.mol
Einecs: 200-002-3
Melting Point: 180-185 °C(lit.)
Boiling point: 132.9 °C at 760 mmHg
Storage Temperature: Store at RT.
Flash Point: 34.2 °C
Density: 1.18 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.465
Water Solubility: 2280 g/L (20 ºC)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates; Miscellaneous Biochemicals
Synonyms of Guanidine hydrochloride (50-01-1): guanidine,monohydrochloride ; guanidinechloride ; guanidinemonohydrochloride ; guanidiniumhydrochloride ; usafek-749 ; carbamidine hydrochloride ; iminourea hydrochloride ; guanidinium chloride .
Uses
Guanidine hydrochloride (50-01-1) is mainly used as a drug intermediate, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and folic acid an important raw material. It also can be used as medicine, pesticide, dyes and other organic synthesis intermediates. Can be used to synthesis of 2 - amino-pyrimidine, 2 - amino -6 - methyl-pyrimidine, 2 - amino -4,6 - dimethyl-pyrimidine, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and other sulfa drugs, intermediates. Guanidine (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4 - 2-amino -6 - hydroxy-pyrimidine, folic acid used for synthesis of anti-anemia drugs. Also be used as synthetic anti-static agent.
Production
Double cyanide-ammonia and ammonium salt (ammonium chloride) as raw materials in the 170-230 ℃ melt under the reaction of guanidine hydrochloride were crude, after refining was finished.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | subcutaneous | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| guinea pig | LDLo | intraarterial | 500mg/kg (500mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
| guinea pig | LDLo | intravenous | 500mg/kg (500mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
| guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| mammal (species unspecified) | LDLo | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931. |
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 571mg/kg (571mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: IRRITABILITY | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993. |
| rabbit | LD | skin | > 2gm/kg (2000mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993. | |
| rat | LD50 | oral | 475mg/kg (475mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Technical Information Service. Vol. AD-A165-747, |
| rat | LDLo | subcutaneous | 404mg/kg (404mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926. |
Safety Profile
Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi.gif){kind=small}
Risk Statements: 22-36/38
22: Harmful if swallowed
36: Irritating to the eyes
38: Irritating to the skin
Safety Statements: 26-36-22
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing