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GUANIDINE HYDROCHLORIDE

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Name

GUANIDINE HYDROCHLORIDE

EINECS 200-002-3
CAS No. 50-01-1 Density 1.18 g/mL at 25 °C(lit.)
PSA 75.89000 LogP 1.14090
Solubility 2280 g/L (20 °C) in water Melting Point 180-185 °C(lit.)
Formula CH5N3.HCl Boiling Point 132.9 °C at 760 mmHg
Molecular Weight 95.5317 Flash Point 34.2 °C
Transport Information N/A Appearance White cryst. powder
Safety 26-36-22 Risk Codes 22-36/38
Molecular Structure Molecular Structure of 50-01-1 (Guanidine hydrochloride) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

Guanidine,monohydrochloride (8CI,9CI);Buffer AL;Guanidine chloride;Guanidinehydrochloride;Guanidinium chloride;Guanidinium hydrochloride;

Article Data 32

GUANIDINE HYDROCHLORIDE Synthetic route

guanidinium trinitromethanide

50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 0℃; Product distribution;78%
1674-62-0

N1-methyl biguanide hydrochloride

A

420-04-2

CYANAMID

B

471-29-4

1-methylguanidine

C

50-01-1

guanidine hydrochloride

D

4674-68-4

methylcyanamide

Conditions
ConditionsYield
bei der thermischen Zersetzung;
50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
With aluminium trichloride; ammonia at 300℃;

N-methylguanidine hydrochloride

2-amino-4,5-dihydro-4,5-dihydroxyimidazolium chloride

A

50-01-1

guanidine hydrochloride

B

1-methyl-2-amino-4,5-dihydro-4,5-dihydroxyimidazolinium chloride

Conditions
ConditionsYield
In chloroform-d1 Equilibrium constant; pH 8;
127099-85-8, 780722-26-1

N-Cyanoguanidine

aqueous ammonium chloride

aqueous ammonium chloride

A

645-93-2

ammelide

B

50-01-1

guanidine hydrochloride

C

56-03-1

BIGUANIDE

Conditions
ConditionsYield
at 150℃;
56-23-5

tetrachloromethane

7664-41-7

ammonia

7553-56-2

iodine

copper

copper

A

74-90-8

hydrogen cyanide

B

460-19-5

ethanedinitrile

C

50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
at 140℃;
64-17-5

ethanol

420-04-2

CYANAMID

ammonium chloride

50-01-1

guanidine hydrochloride

Conditions
ConditionsYield
at 100℃;
7647-01-0

hydrogenchloride

509-14-8

tetranitromethane

nickel coated zinc

nickel coated zinc

A

ammonium chloride

B

50-01-1

guanidine hydrochloride

7664-41-7

ammonia

31407-74-6

O-ethyl-isourea hydrochloride

50-01-1

guanidine hydrochloride

thiocarbimidoic acid O-ethyl ester-S-methyl ester; hydrochloride

concentrated alcoholic ammonia

concentrated alcoholic ammonia

50-01-1

guanidine hydrochloride

GUANIDINE HYDROCHLORIDE Chemical Properties

Product Name: Guanidine hydrochloride (50-01-1)


Molecular Formula: CH6ClN3
Molecular Weight: 95.53g/mol
Mol File: 50-01-1.mol
Einecs: 200-002-3
Melting Point: 180-185 °C(lit.)
Boiling point: 132.9 °C at 760 mmHg
Storage Temperature: Store at RT.
Flash Point: 34.2 °C
Density: 1.18 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.465
Water Solubility: 2280 g/L (20 ºC)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates; Miscellaneous Biochemicals
Synonyms of  Guanidine hydrochloride (50-01-1): guanidine,monohydrochloride ; guanidinechloride ; guanidinemonohydrochloride ; guanidiniumhydrochloride ; usafek-749 ; carbamidine hydrochloride ; iminourea hydrochloride ; guanidinium chloride .

GUANIDINE HYDROCHLORIDE Uses

 Guanidine hydrochloride (50-01-1) is mainly used as a drug intermediate, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and folic acid an important raw material. It also can be used as medicine, pesticide, dyes and other organic synthesis intermediates. Can be used to synthesis of 2 - amino-pyrimidine, 2 - amino -6 - methyl-pyrimidine, 2 - amino -4,6 - dimethyl-pyrimidine, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and other sulfa drugs, intermediates. Guanidine (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4 - 2-amino -6 - hydroxy-pyrimidine, folic acid used for synthesis of anti-anemia drugs. Also be used as synthetic anti-static agent.

GUANIDINE HYDROCHLORIDE Production

Double cyanide-ammonia and ammonium salt (ammonium chloride) as raw materials in the 170-230 ℃ melt under the reaction of guanidine hydrochloride were crude, after refining was finished.

GUANIDINE HYDROCHLORIDE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 200mg/kg (200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
guinea pig LDLo intraarterial 500mg/kg (500mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 500mg/kg (500mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo subcutaneous 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
mammal (species unspecified) LDLo oral 300mg/kg (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 571mg/kg (571mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: IRRITABILITY
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993.
rabbit LD skin > 2gm/kg (2000mg/kg)   Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993.
rat LD50 oral 475mg/kg (475mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. AD-A165-747,
rat LDLo subcutaneous 404mg/kg (404mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926.

GUANIDINE HYDROCHLORIDE Safety Profile

Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/38 
22:  Harmful if swallowed
36:  Irritating to the eyes   
38:  Irritating to the skin 
Safety Statements: 26-36-22
22:  Do not breathe dust
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing

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