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Galanthamine

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Name

Galanthamine

EINECS 609-175-3
CAS No. 357-70-0 Density 1.28 g/cm3
PSA 41.93000 LogP 1.78820
Solubility N/A Melting Point 119-121 °C
Formula C17H21NO3 Boiling Point 439.3 °C at 760 mmHg
Molecular Weight 287.359 Flash Point 219.5 °C
Transport Information N/A Appearance Off-white sSolid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 357-70-0 (Galanthamine) Hazard Symbols N/A
Synonyms

6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl- (7CI);Galanthamine (6CI,8CI);(-)-Galantamine;(-)-Galanthamine;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, [4aS-(4aa,6b,8aR*)]-;BRN 0093736;Galantamin;Galantamina;Jilkon;Lycoremin;Lycoremine;NSC 100058;(+)Galanthamine;736-79-8;

Article Data 44

Galanthamine Specification

The Galantamine is an organic compound with the formula C17H21NO3. The systematic name of this chemical is galanthamine. With the CAS registry number 357-70-0, it is also named as 3,4-Dihydrogalanthamine. The product's categories are All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is an off-white solid, which is used for the treatment of mild to moderate Alzheimer's disease and various memory impairments. Galantamine is indicated for mild to moderate Vascular Dementia and Alzheimer.

Physical properties about Galantamine are: (1)ACD/LogP: 1.75; (2)ACD/LogD (pH 5.5): -0.59; (3)ACD/LogD (pH 7.4): 1.12; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2.94; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 49.83; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 30.93 Å2; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 80.31 cm3; (14)Molar Volume: 223.9 cm3; (15)Polarizability: 31.83×10-24cm3; (16)Surface Tension: 56.6 dyne/cm; (17)Density: 1.28 g/cm3; (18)Flash Point: 219.5 °C; (19)Enthalpy of Vaporization: 73.39 kJ/mol; (20)Boiling Point: 439.3 °C at 760 mmHg; (21)Vapour Pressure: 1.71E-08 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C
(2)InChI: InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(3)InChIKey: ASUTZQLVASHGKV-JDFRZJQEBY
(4)Std. InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(5)Std. InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 10mg/kg (10mg/kg)   Journal of Medicinal Chemistry. Vol. 37, Pg. 689, 1994.
mouse LD50 subcutaneous 14mg/kg (14mg/kg)   United States Patent Document. Vol. #4550113,
rat LD50 intraperitoneal 22900mg/kg (22900mg/kg)   United States Patent Document. Vol. #5177082,

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