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Basic information

  • Name:
  • Ganciclovir

  • CAS No.:
  • 82410-32-0

  • Formula:
  • C9H13N5O4
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Chemistry


IUPAC Name: 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
Molecular Formula: C9H13N5O4 
Molecular Weight: 255.23 g/mol
Canonical SMILES: c12c(ncn1COC(CO)CO)c([nH]c(n2)N)=O
InChI: InChI=1/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
Classification Code: Anti-Infective Agents; Antiviral; Antiviral agents; Drug / Therapeutic Agent; Mutation data
Product Categories: Bases & Related Reagents; Intermediates & Fine Chemicals; Nucleotides; Pharmaceuticals; API's; Antiviral
Index of Refraction: 1.76 
Molar Refractivity: 57.9 cm
Molar Volume: 140.5 cm3 
Polarizability: 22.95×10-24 cm
Surface Tension: 86.6 dyne/cm 
Density: 1.81 g/cm
Flash Point: 362 °C 
Enthalpy of Vaporization: 104.13 kJ/mol 
Boiling Point: 675 °C at 760 mmHg 
Melting Point: 250 °C
storage temperature: 2-8 °C
solubility: 0.1 M HCl: 10 mg/mL
Vapour Pressure of Ganciclovir (CAS NO.82410-32-0): 3.82E-19 mmHg at 25 °C

Uses

 Ganciclovir (CAS NO.82410-32-0) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 291, 1990.
dog LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 291, 1990.
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg)   Journal of Medicinal Chemistry. Vol. 26, Pg. 759, 1983.
mouse LD50 intravenous 900mg/kg (900mg/kg)   Drugs in Japan Vol. -, Pg. 291, 1990.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 291, 1990.

Safety Profile

Common adverse drug reactions >=1% of patients) include: neutropenia, granulocytopenia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhoea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, anaemia, pain and phlebitis at injection site (due to high pH), sweating, rash.
Hazard Codes: ToxicT
Risk Statements: 46-60-61 
R46:May cause heritable genetic damage. 
R60:May impair fertility. 
R61:May cause harm to the unborn child.
Safety Statements: 53-36/37/39-45 
S53:Avoid exposure - obtain special instructions before use. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS of Ganciclovir (CAS NO.82410-32-0): MF8407000

Specification

 Ganciclovir (CAS NO.82410-32-0), its Synonyms are 2'-NDG ; 2'-Nor-2'-deoxyguanosine ; 2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one ; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- ; 9-((1,3-Dihydroxy-2-propoxy)methyl)guanine ; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine ; Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)- ; Hydroxyacyclovir . It is white powder.

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