Gemifloxacin (175463-14-6),Gemifloxacin (175463-14-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Gemifloxacin
Superlist Name:
Gemifioxacin
CAS No.:
175463-14-6
Molecular Structure:
Formula:
C₁₈H₂₀FN₅O₄
Molecular Weight:
389.39
Deleted CAS:
204519-64-2,214346-11-9,210353-52-9
Synonyms:
7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;1,8-naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-;(Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;
Density:
1.648 g/cm³
Boiling Point:
638.919 °C at 760 mmHg
Flash Point:
340.206 °C

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Chemistry

Molecular Structure of Gemifloxacin (CAS NO.175463-14-6):

IUPAC Name: 7-[(4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Molecular Formula: C₁₈H₂₀FN₅O₄
Molecular Weight: 389.39
H bond acceptors: 9
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 121.35Å²
Density: 1.64g/cm³
Boiling Point: 638.9°Cat760mmHg
Flash Point: 340.2°C
Index of Refraction: 1.735
Surface Tension: 66.121 dyne/cm
Enthalpy of Vaporization: 99.166 kJ/mol
Vapour Pressure: 0 mmHg at 25°C
Product Categories: API; pharmaceutical intermediates
Synonyms: (Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid ; 1,8-naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo- ; 7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Toxicity Data With Reference

The serious events may occur with therapeutic or with acute overdose including central nervous system toxicity, cardiovascular toxicity, tendon / articular toxicity and rarely hepatic toxicity. It is harmful with fluoroquinolones than with other antibiotic drug classes include CNS and tendon toxicity.

Safety Profile

Gemifloxacin (CAS NO.175463-14-6) has safety profiles similar to that of other antimicrobial classes.

Specification

Gemifloxacin (CAS NO.175463-14-6) is an oral broad-spectrum quinolone antibacterial agent which is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia.